Antinociception Induced by Moringa Stenopetela (Baker f.) Cufod. Leaves Extract and Possible Mechanisms of Action

Moringa stenopetala (Baker f.) Cufod., is an endemic species growing in the south of Ethiopia. M. often consumed as food and used traditional medicine it has also been traditionally for relieving pain This study aimed to investigate antinociceptive effect mechanisms action leaves methanol extract mice. The per-oral doses 50, 100, 200 mg/kg were tested by using hot-plate, tail-immersion, writhing tests. possible investigated pre-treatment with 5 naloxone (non-selective opioid antagonist), 1 ketanserin (5-HT2A/2C receptor yohimbine (α2 adrenoceptor antagonist). showed all significant involvement 5-HT2A/2C receptors α2 adrenoceptors antinociception induced hot-plate tail-immersion tests, well contribution test, identified. In conclusion, these findings demonstrate that potential management. Thisstudywillcontributetonewtherapeuticapproachesandprovideguidancefornewdrug development studies.